Efficacy of topical photodynamic therapy in the treatment of erythroplasia of Queyrat

  • Massimo Iafrate | massimo.iafrate@unipd.it Urology Clinic, Department of Surgery, Oncology and Gastroenterology - Urology Clinic, University of Padua, Italy.
  • Mariangela Mancini Urology Clinic, Department of Surgery, Oncology and Gastroenterology - Urology Clinic, University of Padua, Italy.
  • Tommaso Prayer Galetti Urology Clinic, Department of Surgery, Oncology and Gastroenterology - Urology Clinic, University of Padua, Italy.
  • Serena Szekely Unit of Dermatology, Department of Medicine, University of Padova, Padua, Italy.
  • Edoardo Zattra Unit of Dermatology, Department of Medicine, University of Padova, Italy.
  • Daniele Vaccari Unit of Dermatology, Department of Medicine, University of Padova, Padua, Italy.
  • Stefano Piaserico Unit of Dermatology, Department of Medicine, University of Padova, Padua, Italy.

Abstract

Erythroplasia of Queyrat (EQ) is an intraepidermal carcinoma in situ presenting clinically as a sharply demarcated, slightly raised erythematosus plaque on the glans penis or the inner side of the foreskin. Various treatment modalities for EQ have been proposed, including electrocautery and curettage, topical 5-floururacil cream, imiquimod cream, isotretinoin, cryotherapy, laser therapy, radiotherapy, ingenol mebutate gel and photodynamic therapy (PDT). Most of these treatments are limited by low clearance rates and frequent relapses. Surgical treatment including local excision, Mohs micrographic surgery and partial or total penectomy, ensures adequate healing rates. However, discomfort consequent to surgical treatment might be unacceptable. Topical PDT using the methyl ester of 5-aminolaevulinic acid (MAL) is an established non-surgical treatment of cutaneous precancerous lesions and skin cancers. We present the case of a 60-year-old uncircumcised man affected by EQ of the penis successfully treated with MAL-PDT, performed five times, two weeks apart, with no recurrences after 6 years.

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Published
2020-06-25
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Section
Case Reports
Keywords:
Erythroplasia of Queyrat, carcinoma in situ, photodynamic therapy
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How to Cite
Iafrate, M., Mancini, M., Prayer Galetti, T., Szekely, S., Zattra, E., Vaccari, D., & Piaserico, S. (2020). Efficacy of topical photodynamic therapy in the treatment of erythroplasia of Queyrat. Dermatology Reports, 12(1). https://doi.org/10.4081/dr.2020.8566