Therapeutic management of a symptomatic Kaposi’s sarcoma patient with renal failure undergoing haemodialysis: A case report


https://doi.org/10.4081/dr.2022.9113
Vol. 14 No. 1 (2022)
Submitted: 26 February 2021
Accepted: 21 June 2021
Published: 29 October 2021
Kaposi sarcoma, Human herpesvirus 8, Chronic renal impairment, Haemodialysis, Pomalidomide
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Authors

  • Anna Passarelli
    passarellian@libero.it
    Unit of Medical Oncology, Department of Onco-Hematology, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), Rionero in Vulture (PZ); Department of Urology and Gynecology, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Naples, Italy.
  • Giovanna Galdo Oncologic Dermatology Unit, Department of Onco-Hematology, IRCCS-CROB, Centro di Riferimento Oncologico della Basilicata (IRCCSCROB), Rionero in Vulture (PZ), Italy.
  • Teresa Pellegrino Nuclear Medicine Department, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), Rionero in Vulture (PZ), Italy. https://orcid.org/0000-0003-2010-5865
  • Giandomenico Roviello Department of Health Sciences, University of Florence, Italy.
  • Michele Aieta Unit of Medical Oncology, Department of Onco-Hematology, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), Rionero in Vulture (PZ), Italy.
  • Gabriella Aviello Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
  • Raffaele Conca Unit of Medical Oncology, Department of Onco-Hematology, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), Rionero in Vulture (PZ), Italy. https://orcid.org/0000-0003-0683-5474

Kaposi’s sarcoma (KS) is a rare inflammation- based vascular cancer involving the skin. The viral aetiology of KS is the Human Herpesvirus 8. KS may be frequently diagnosed in immunosuppressed kidneytransplanted patients, while is less common in patients with dialysis. It is known that various immunological abnormalities can lead to impaired immune status in uremic patients. It is noteworthy that despite the incidence of KS in patients with renal impairment, only few cases have reported efficacy and safety profile of KS targeting anti-cancer drugs in this kidney disease population. Herein, we report the first case of a symptomatic KS patient with renal disease in haemodialysis and focus on its therapeutic management. We also review the main data available from literature regarding the safety of KS therapy in dialysis patients.


Passarelli, A., Galdo, G., Pellegrino, T., Roviello, G., Aieta, M. ., Aviello, G. ., & Conca, R. (2021). Therapeutic management of a symptomatic Kaposi’s sarcoma patient with renal failure undergoing haemodialysis: A case report. Dermatology Reports, 14(1). https://doi.org/10.4081/dr.2022.9113

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