Correlation between serum 25(OH)D levels with severity of work-related hand eczema among healthcare workers: a cross-sectional study
https://doi.org/10.4081/dr.2023.9861
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Background. Hand eczema (HE) commonly occurs in healthcare services, especially during COVID-19 pandemic era. Vitamin D shows various effects on skin inflammation. This study aims to analyze the correlation between HE severity and vitamin D levels as measured by serum 25(OH)D in healthcare workers. Method. This is an analytic descriptive study with a cross-sectional design conducted in Indonesia between September-October 2022. HE severity was assessed using Hand Eczema Severity Index (HECSI). Results. Among 44 healthcare workers with HE, 29 people had mild HE, 11 had moderate HE, and 4 had severe HE. The mean serum 25(OH)D level in subjects with mild, moderate, and severe HE was 17.85 ng/mL, 16.45 ng/mL, and 17.87 ng/mL, respectively, which belonged to vitamin D deficiency category. There was no statistically significant correlation between serum 25(OH)D levels and HE severity (r = -0.056; p = 0.359). Conclusions. There was no significant difference in serum 25(OH)D levels between subjects with mild, moderate, and severe HE. Serum 25(OH)D level was not inversely correlated with HE severity.
Capucci S, Hahn-Pedersen J, Vilsboll A, Kragh N. Impact of atopic dermatitis and chronic hand eczema on quality of life compared with other chronic diseases. Dermatitis. 2020;31:178-84. DOI: https://doi.org/10.1097/DER.0000000000000598
Quaade AS, Simonsen AB, Halling AS, et al. Prevalence, incidence, and severity of hand eczema in the general population - A systematic review and meta-analysis. Contact Dermatitis. 2021;84:361-74. DOI: https://doi.org/10.1111/cod.13804
Yusuf RS, Qurratuaini BPA, Hidajat D. Efek hand hygiene terhadap dermatitis tangan. JKU Unram. 2021;10:480-6. DOI: https://doi.org/10.29303/jku.v10i2.505
Rundle CW, Presley CL, Militello M, et al. Hand hygiene during COVID-19: Recommendations from the American Contact Dermatitis Society. J Am Acad Dermatol. 2020;83:1730-7. DOI: https://doi.org/10.1016/j.jaad.2020.07.057
Sawitri, Astindari, Yuindartanto A, et al. Epidemiology of occupational contact dermatitis (OCD) on health workers in Covid-19. J Pak Assoc Dermatol. 2023;33:220-34.
Samanta S. Vitamin D and immunomodulation in the skin: A useful affirmative nexus. Exploration of Immunology. 2021. DOI: https://doi.org/10.37349/ei.2021.00009
Amon U, Baier L, Yaguboglu R, et al. Serum 25-hydroxyvitamin D levels in patients with skin diseases including psoriasis, infections, and atopic dermatitis. Dermatoendocrinol. 2018;10:e1442159. DOI: https://doi.org/10.1080/19381980.2018.1442159
Suryadinata RV, Lorensia A, Aprilia AP. Profil vitamin D pada pasien asma dan non-asma dewasa di Surabaya. IJPH. 2017;12. DOI: https://doi.org/10.20473/ijph.v12i1.2017.106-117
Held E, Skoet R, Johansen JD, Agner T. The hand eczema severity index (HECSI): A scoring system for clinical assessment of hand eczema. A study of inter- and intraobserver reliability. Br J Dermatol. 2005;152:302-7. DOI: https://doi.org/10.1111/j.1365-2133.2004.06305.x
Park JB, Lee SH, Kim KJ, et al. Clinical features and awareness of hand eczema in Korea. Ann Dermatol. 2016;28:335-43. DOI: https://doi.org/10.5021/ad.2016.28.3.335
Safizadeh H, Shamsi‐Meymandy S, Nasri L, Shamsi‐Meymandy M. Quality of life among patients with hand eczema in Iran. RusOMJ. 2013;2:1-4. DOI: https://doi.org/10.1155/2012/571516
Georgieva FG. Hand eczema and its impact on wellbeing and quality of life of patients. J of IMAB. 2017;23:1490-4. DOI: https://doi.org/10.5272/jimab.2017231.1490
Madan I, Parsons V, Cookson B, et al. A behavioural change package to prevent hand dermatitis in nurses working in the national health service (the SCIN trial): study protocol for a cluster randomised controlled trial. Trials. 2016;17:145. DOI: https://doi.org/10.1186/s13063-016-1255-y
Celik V, Ozkars MY. An overlooked risk for healthcare workers amid COVID-19: Occupational hand eczema. North Clin Istanb. 2020;7:527-33. DOI: https://doi.org/10.14744/nci.2020.45722
Techasatian L, Thaowandee W, Chaiyarit J, et al. Hand hygiene habits and prevalence of hand eczema during the COVID-19 pandemic. J Prim Care Community Health. 2021;12:1-5. DOI: https://doi.org/10.1177/21501327211018013
Loh EW, Yew YW. Hand hygiene and hand eczema: A systematic review and meta-analysis. Contact Dermatitis. 2022. DOI: https://doi.org/10.1111/cod.14133
Nopriyati, Trilisnawati D, Yulia Farida Y, et al. Prevention of irritant contact dermatitis due to hand hygiene in the era of COVID 19 pandemic. BSM. 2020;4:29-44. DOI: https://doi.org/10.32539/bsm.v4i4.160
Desira ADD, Riyanto P, Afriliana L, Adespin DA. Relationship of hand sanitizer usage frequency with the incidence of irritant contact dermatitis during Covid-19 pandemic. JKD. 2022;11:109-13. DOI: https://doi.org/10.14710/dmj.v11i2.32631
Kodik MS, Çetin ZD, Unal İ, Altuncı YA. The prevalence and risk factors of hand eczema among emergency healthcare workers during the COVID-19 pandemic. Ege Tip Dergisi. 2021;60:155-62. DOI: https://doi.org/10.19161/etd.951013
Alkhalifah A. Risk factors for hand eczema in the general population of Saudi Arabia during the COVID-19 pandemic: An internet-based cross-sectional study. JAAD Int. 2022;6:119-24. DOI: https://doi.org/10.1016/j.jdin.2021.12.011
Hamnerius N, Svedman C, Bergendorff O, et al. Hand eczema and occupational contact allergies in healthcare workers with a focus on rubber additives. Contact Dermatitis. 2018;79:149-56. DOI: https://doi.org/10.1111/cod.13042
Behroozy A, Keegel TG. Wet-work exposure: A main risk factor for occupational hand dermatitis. Saf Health Work. 2014;5:175-80. DOI: https://doi.org/10.1016/j.shaw.2014.08.001
Loman L, Politiek K, Schuttelaar MLA. Smoking and obesity are associated with chronic hand eczema and severity of hand eczema: Data from the Dutch general population. Contact Dermatitis. 2022;87:103-6. DOI: https://doi.org/10.1111/cod.14110
Charan UP, Peter CV, Pulimood SA. Impact of hand eczema severity on quality of life. Indian Dermatol Online J. 2013;4:102-5. DOI: https://doi.org/10.4103/2229-5178.110629
Mahajan BB, Kaur S. Impact of hand eczema severity on quality of life: a hospital based cross-sectional study. Our Dermatology Online. 2016;7:1-4. DOI: https://doi.org/10.7241/ourd.20161.1
Varma R, Devi K, Asokan N. A Cross-Sectional Analysis on Hand Eczema: Severity and Quality of Life. Indian Dermatol Online J. 2021;12:952-3. DOI: https://doi.org/10.4103/2229-5178.330844
Sari DK, Sari LM, Laksmi LI, Farhat. The moderate correlation between 25(OH)D serum and saliva in healthy people with low vitamin D intake. Int J Gen Med. 2021;14:841-50. DOI: https://doi.org/10.2147/IJGM.S302912
Methkal AM, Kuts LV. The investigation of the dependence between hand eczema severity and some cytokine profile parameters, vitamin D level, and glucocorticoid receptor gene polymorphism. Ukraïnsʹkij žurnal medicini, bìologìï ta sportu. 2020;5:164-9. DOI: https://doi.org/10.26693/jmbs05.05.164
Huang CM, Lara-Corrales I, Pope E. Effects of vitamin D levels and supplementation on atopic dermatitis: A systematic review. Pediatr Dermatol. 2018;35:754-60. DOI: https://doi.org/10.1111/pde.13639
Hafsia M, Kacem I, El Maalel O, et al. Relationship between hand eczema severity and occupational stress: A cross-sectional study. Dermatol Res Pract. 2019;2019:8301896. DOI: https://doi.org/10.1155/2019/8301896
Copyright (c) 2023 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Downloads
Citations
