A review of giardiasis and its parasite genotypes in Iran


Submitted: 30 November 2020
Accepted: 14 June 2021
Published: 12 July 2021
Abstract Views: 1094
PDF: 248
Appendix: 51
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Authors

Giardia lamblia is one of the most prevailing intestinal protozoa in many vertebrates like humans, domestic and wild animals. Molecular studies show that Giardia lamblia is a complex parasite. Currently, giardiasis disease is one of the main problems of social and personal health in different countries around the world. Giardia is known as a zoonotic parasite that is divided into eight genetic assemblages (A to H). In this review study, by referring to the molecular epidemiology of Giardia lamblia and emphasizing its zoonotic factors, the background of Giardia and its genotypes in Iran have been studied. The study population consisted of indexed articles in reputable databases such as Scopus, Magiran, SID, Science Direct, PubMed, and Google Scholar in Iran from 1990 to 2020. Based on limited studies in Iran, assemblage BIII and AII are the most common types of Giardia assemblages. Therefore, it is necessary to conduct comprehensive studies on various human and animal isolates in different areas of the country, especially places where no researches have been done.


Lalle M, Pozio E, Capelli G, et al. Genetic heterogeneity at the beta-giardin locus among human and animal isolates of Giardiaduodenalis and identification of potentially zoonotic subgenotypes. Int J Parasitol 2005;35:207-13. DOI: https://doi.org/10.1016/j.ijpara.2004.10.022

Fricker C, Medema G, Smith H. Protozoan parasites (Cryptosporidium, Giardia, Cyclospora). Guidelines for Drinking-Water Quality 2002;2:70-118.

Hardy S. Topley and Wilson's Microbiology and Microbial Infections: Parasitology. Br J Biomed Sci 2007;64:190.

Thompson RC. The zoonotic significance and molecular epidemiology of Giardia and giardiasis. Vet Parasitol 2004;126:15-35. DOI: https://doi.org/10.1016/j.vetpar.2004.09.008

Behrman RE, Kliegman R, Nelson WE. Nelson textbook of pediatrics. Philadelphia: W.B. Saunders; 1996.

Prucca CG, Slavin I, Quiroga R, et al. Antigenic variation in Giardia lamblia is regulated by RNA interference. Nature 2008;456:750-4. DOI: https://doi.org/10.1038/nature07585

Koot BG, ten Kate FJ, Juffrie M, et al. Does Giardia lamblia cause villous atrophy in children?: A retrospective cohort study of the histological abnormalities in giardiasis. J Pediatr Gastroenterol Nutr 2009;49:304-8. DOI: https://doi.org/10.1097/MPG.0b013e31818de3c4

Adam RD. Biology of Giardia lamblia. Clin Microbiol Rev 2001;14:447-75. DOI: https://doi.org/10.1128/CMR.14.3.447-475.2001

Kamda JD, Singer SM. Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia. Infect Immun 2009;77:685-93. DOI: https://doi.org/10.1128/IAI.00718-08

Astiazaran-Garcia H, Quintero J, Vega R, et al. Identification of T-cell stimulating antigens from Giardia lamblia by using Giardia-specific T-cell hybridomas. Parasite Immunol 2009;31:132-9. DOI: https://doi.org/10.1111/j.1365-3024.2008.01083.x

Andersen YS, Gillin FD, Eckmann L. Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia spp. Infect Immun 2006;74:2473-6. DOI: https://doi.org/10.1128/IAI.74.4.2473-2476.2006

Fraser D, Bilenko N, Deckelbaum RJ, et al. Giardia lamblia Carriage in Israeli Bedouin Infants: Risk Factors and Consequences. Clin Infect Dis 2000;30:419-24. DOI: https://doi.org/10.1086/313722

Quihui-Cota L, Astiazarán-García H, Valencia ME, et al. Impact of Giardia intestinalis on vitamin a status in schoolchildren from northwest Mexico. Int J Vitam Nutr Res 2008;78:51-6. DOI: https://doi.org/10.1024/0300-9831.78.2.51

Müller J, Ley S, Felger I, et al. Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole. J Antimicrob Chemother 2008;62:72-82. DOI: https://doi.org/10.1093/jac/dkn142

Saffar MJ, Qaffari J, Khalilian AR, Kosarian M. Rapid reinfection by Giardia lamblia after treatment in a hyperendemic area: the case against treatment. East Mediterr Health J 2005;11:73-8.

Gilman R, Miranda E, Marquis G, et al. Rapid reinfection by Giardia lamblia after treatment in a hyperendemic third world community. Lancet 1988;331:343-5. DOI: https://doi.org/10.1016/S0140-6736(88)91131-2

Shukla G, Devi P, Sehgal R. Effect of Lactobacillus casei as a Probiotic on Modulation of Giardiasis. Digest Dis Sci 2008;53:2671-9. DOI: https://doi.org/10.1007/s10620-007-0197-3

Upton SJ, Zien CA. Description of a Giardia varani-like flagellate from a water monitor, Varanus salvator, from Malaysia. J Parasitol 1997;83:970-1. DOI: https://doi.org/10.2307/3284303

Monis PT, Mayrhofer G, Andrews RH, et al. Molecular genetic analysis of Giardia intestinalis isolates at the glutamate dehydrogenase locus. Parasitology 1996;112:1-12. DOI: https://doi.org/10.1017/S0031182000065021

Lu S, Wen J, Li J, Wang F. DNA sequence analysis of the triose phosphate isomerase gene from isolates of Giardia lamblia. Chin Med J (Engl) 2002;115:99-102.

Sulaiman IM, Fayer R, Bern C, et al. Triosephosphate Isomerase Gene Characterization and Potential Zoonotic Transmission of Giardia duodenalis. Emerg Infect Dis J 2003;9:1444. DOI: https://doi.org/10.3201/eid0911.030084

Thompson RC, Monis PT. Variation in Giardia: implications for taxonomy and epidemiology. Adv Parasitol 2004;58:69-137. DOI: https://doi.org/10.1016/S0065-308X(04)58002-8

Thompson RC, Meloni BP. Molecular variation in Giardia. Acta Trop 1993;53:167-84. DOI: https://doi.org/10.1016/0001-706X(93)90028-A

Lasek-Nesselquist E, Welch DM, Sogin ML. The identification of a new Giardia duodenalis assemblage in marine vertebrates and a preliminary analysis of G. duodenalis population biology in marine systems. Int J Parasitol 2010;40:1063-74. DOI: https://doi.org/10.1016/j.ijpara.2010.02.015

Rafiei A, Roointan ES, Samarbafzadeh AR, et al. Investigation of possible correlation between Giardia duodenalis genotypes and clinical symptoms in southwest of Iran. Iran J Parasitol 2013;8:389-95.

Pestechian N, Rasekh H, Rostami-Nejad M, Yousofi HA, Hosseini-Safa A. Molecular identification of Giardia lamblia; is there any correlation between diarrhea and genotyping in Iranian population? Gastroenterol Hepatol Bed Bench 2014;7:168-72.

Hoque ME, Hope VT, Kjellström T, Scragg R, Lay-Yee R. Risk of giardiasis in Aucklanders: a case-control study. Int J Infect Dis 2002;6:191-7. DOI: https://doi.org/10.1016/S1201-9712(02)90110-4

Sprong H, Cacciò SM, van der Giessen JW. Identification of zoonotic genotypes of Giardia duodenalis. PLoS Negl Trop Dis 2009;3:e558. DOI: https://doi.org/10.1371/journal.pntd.0000558

Jafari H, Jalali MHR, Shapouri MSA, Hajikolaii MRH. Determination of Giardia duodenalis genotypes in sheep and goat from Iran. J Parasit Dis 2014;38:81-4. DOI: https://doi.org/10.1007/s12639-012-0199-8

Faridi A, Kareshk A, Sadooghian S, Firouzeh N. Frequency of different genotypes of Giardia duodenalis in slaughtered sheep and goat in east of iran. J Parasitic Dis 2020;44. DOI: https://doi.org/10.1007/s12639-020-01237-1

Kiani-Salmi N, Fattahi-Bafghi A, Astani A, Sazmand A, Zahedi A, Firoozi Z, et al. Molecular typing of Giardia duodenalis in cattle, sheep and goats in an arid area of central Iran. Infect Genet Evol 2019;75:104021. DOI: https://doi.org/10.1016/j.meegid.2019.104021

Homayouni MM, Razavi SM, Shaddel M, Asadpour M. Prevalence and molecular characterization of Cryptosporidium spp. and Giardia intestinalis in household dogs and cats from Shiraz, Southwestern Iran. Vet Ital 2019;55:311-8.

Gharekhani J. Study on gastrointestinal zoonotic parasites in pet dogs in Western Iran. Turkiye Parazitol Derg 2014;38:172-6. DOI: https://doi.org/10.5152/tpd.2014.3546

Kohansal MH, Fazaeli A, Nourian A, Haniloo A, Kamali K. Dogs' gastrointestinal parasites and their association with public health in Iran. J Vet Res 2017;61:189-95. DOI: https://doi.org/10.1515/jvetres-2017-0024

Mosallanejad B, Avizeh R, Razi Jalali MH. Detection of Giardia duodenalis antigen in companion rabbits of Ahvaz district, South-West of Iran. Iranian J Vet Sci Technol 2016;8:58-63.

Mosallanejad B, Avizeh R, Jalali MR, Alborzi A. Prevalence of Giardia duodenalis infection in household cats of Ahvaz District, south-west of Iran. Iran J Parasitol 2010;5:27-34.

Malekifard F, Ahmadpour M. Molecular detection and identification of Giardia duodenalis in cattle of Urmia, northwest of Iran. Vet Res Forum 2018;9:81-5.

Arbabi M, Doroodgar A, Hoshyar H, Asadi MA. Evaluation of Giardia and Sarcocystis contamination in dog-related animals in Kashan region during the years 1999-2001. KAUMS J (FEYZ) 2001;5:83-9.

Shirani D, Khalili M, Meshki B. The prevalence of giardia in fection in companion dogs, Esfahan. J Tehran Univ Vet Res 2006;61:161-3.

Organization WH. Prevention and control of intestinal parasitic infections: report of a WHO Expert Committee [meeting held in Geneva from 3 to 7 March 1986]: World Health Organization; 1987.

Fakhar M, Kialashaki E, Sharif M. An Overview on the present Situation of Giardiasis in Iran and the World with Emphasis on Zoonotic Aspects. J Mazandaran Univ Med Sci 2014;24:235-51.

Hemmati N, Razmjou E, Hashemi-Hafshejani S, et al. Prevalence and Risk Factors of Human Intestinal Parasites in Roudehen, Tehran Province, Iran. Iran J Parasitol 2017;12:364-73.

Vahedi M, Gohardehi S, Sharif M, Daryani A. Prevalence of parasites in patients with gastroenteritis at East of Mazandaran Province, Northern Iran. Trop Biomed 2012;29:568-74.

Kiani H, Haghighi A, Rostami A, Azargashb E, Seyyedtabaei S, Solgi A, et al. Prevalence, risk factors and symptoms associated to intestinal parasite infections among patients with gastrointestinal disorders in Nahavand, Western Iran. Revista do Instituto de Medicina Tropical de São Paulo 2016;58. DOI: https://doi.org/10.1590/S1678-9946201658042

Norouzi P, Mohaghegh M-A, Ghorbani M, et al. Investigating the prevalence of intestinal parasites with an emphasis on Strongyloides stercoralis infection in hospitalized patients: a regional report from Iran. Ann Parasitol. 2020;66(3):365-71.

Abbaszadeh Afshar MJ, Barkhori Mehni M, Rezaeian M, et al. Prevalence and associated risk factors of human intestinal parasitic infections: a population-based study in the southeast of Kerman province, southeastern Iran. BMC Infect Dis 2020;20:12. DOI: https://doi.org/10.1186/s12879-019-4730-8

Kuzehkanani AB, Rezaei S, Babaei Z, et al. Enteric protozoan parasites in rural areas of bandar-abbas, southern iran: comparison of past and present situation. Iranian J Public Health 2011;40:80-5.

Sharifdini M, Ghanbarzadeh L, Barikani A, Saraei M. Prevalence of Intestinal Parasites among Rural Inhabitants of Fouman, Guilan Province, Northern Iran with Emphasis on Strongyloides stercoralis. Iran J Parasitol 2020;15:91-100. DOI: https://doi.org/10.18502/ijpa.v15i1.2531

Jafari R, Sharifi F, Bagherpour B, Safari M. Prevalence of intestinal parasites in Isfahan city, central Iran, 2014. J Parasit Dis 2016;40:679-82. DOI: https://doi.org/10.1007/s12639-014-0557-9

Pagheh AS, Sharif M, Daryani A, et al. A cross-sectional analysis of intestinal parasitic infections among the general population in north of Iran. J Infect Devel Countries 2018;12(2):120-6. DOI: https://doi.org/10.3855/jidc.9512

Sobati H. Epidemiological study of parasitic infections in BuMusa Island, Hormozgan. Iran J Parasitol 2020;15:425-34. DOI: https://doi.org/10.18502/ijpa.v15i3.4208

Sarkari B, Hosseini G, Motazedian MH, et al. Prevalence and risk factors of intestinal protozoan infections: a population-based study in rural areas of Boyer-Ahmad district, Southwestern Iran. BMC Infect Dis 2016;16:703. DOI: https://doi.org/10.1186/s12879-016-2047-4

Pestehchian N, Nazari M, Haghighi A, et al. Prevalence of intestinal parasitic infection among inhabitants and tribes of Chelgerd, Iran, 2008-2009. J Clin Diagn Res 2015;9:LC01-4. DOI: https://doi.org/10.7860/JCDR/2015/11580.5879

Sadeghi H, Bakht M, Saghafi H, Shahsavari T. Prevalence of intestinal parasites in a population in Eghbalieh city from Qazvin Province, Iran. J Parasit Dis 2015;39:126-9. DOI: https://doi.org/10.1007/s12639-013-0366-6

Barkhori Mahni M, Rezaeian M, Kia EB, et al. Prevalence of Intestinal Parasitic Infections in Jiroft, Kerman Province, Iran. Iran J Parasitol 2016;11:232-8.

Taherkhani K, Barikani A, Shahnazi M, Saraei M. Prevalence of Intestinal Parasites among Rural Residents of Takestan in North-West of Iran. Iran J Parasitol 2019;14:657-63. DOI: https://doi.org/10.18502/ijpa.v14i4.2118

Alasvand Javadi R, Kazemi F, Fallahizadeh S, Arjmand R. The Prevalence of Intestinal Parasitic Infections in Ahvaz, Southwest of Iran, during 2007-2017. Iran J Public Health 2019;48:2070-3. DOI: https://doi.org/10.18502/ijph.v48i11.3527

Soltani S, Salmanzadeh S, Soltani S, et al. Prevalence of Intestinal Parasitic Infections in the Southwest of Iran: A Four-year Retrospective Study. Infect Disord Drug Targets 2020;20:854-9. DOI: https://doi.org/10.2174/1871526519666191113105043

Karami S, Beiromvand M, Kohansal K. Prevalence of intestinal parasitic infections among diarrheic patients from Ahvaz, southwestern Iran. Infect Disord Drug Targets 2020: doi: 10.2174/1871526520999201116202411. Online ahead of print. DOI: https://doi.org/10.2174/1871526520999201116202411

Fallahi S, Rostami A, Mohammadi M, Ebrahimzadeh F, Pournia Y. Practical parasitology courses and infection with intestinal parasites in students. J Infect Public Health 2016;9:654-60. DOI: https://doi.org/10.1016/j.jiph.2015.12.010

Taheri F, Namakin K, Zarban A, Sharifzadeh G. Intestinal Parasitic Infection among School Children in South Khorasan Province, Iran. J Res Health Sci 2011;11:45-50.

Masoumeh R, Farideh T, Mitra S, Heshmatollah T. Intestinal parasitic infection among school children in Golestan province, Iran. Pak J Biol Sci 2012;15:1119-25. DOI: https://doi.org/10.3923/pjbs.2012.1119.1125

Ashtiani MTH, Monajemzadeh M, Saghi B, et al. Prevalence of intestinal parasites among children referred to Children's Medical Center during 18 years (1991-2008), Tehran, Iran. Ann Trop Med Parasitol 2011;105:507-12. DOI: https://doi.org/10.1179/1364859411Y.0000000040

Daryani A, Sharif M, Nasrolahei M, Khalilian A, Mohammadi A, Barzegar G. Epidemiological survey of the prevalence of intestinal parasites among schoolchildren in Sari, northern Iran. Trans Royal Soc Trop Med Hygiene 2012;106:455-9. DOI: https://doi.org/10.1016/j.trstmh.2012.05.010

Turki H, Hamedi Y, Heidari-Hengami M, et al. Prevalence of intestinal parasitic infection among primary school children in southern Iran. J Parasit Dis 2017;41:659-65. DOI: https://doi.org/10.1007/s12639-016-0862-6

Kheirandish F, Tarahi M, Haghighi A, et al. Prevalence of intestinal parasites in bakery workers in khorramabad, lorestan iran. Iran J Parasitol 2011;6:76-83.

Sharif M, Daryani A, Kia E, et al. Prevalence of intestinal parasites among food handlers of Sari, Northern Iran. Rev Inst Med Trop Sao Paulo 2015;57:139-44. DOI: https://doi.org/10.1590/S0036-46652015000200007

Kheirandish F, Tarahi MJ, Ezatpour B. Prevalence of intestinal parasites among food handlers in Western Iran. Rev Inst Med Trop Sao Paulo 2014;56:111-4. DOI: https://doi.org/10.1590/S0036-46652014000200004

Balarak D, Modrek MJ, Bazrafshan E, et al. Prevalence of intestinal parasitic infection among food handlers in northwest Iran. J Parasitol Res 2016;2016:8461965. DOI: https://doi.org/10.1155/2016/8461965

Heydari-Hengami M, Hamedi Y, Najafi-Asl M, Sharifi-Sarasiabi K. Prevalence of intestinal parasites in food handlers of Bandar Abbas, southern Iran. Iran J Public Health 2018;47:111-8.

Shahnazi M, Abdollahpour H, Alipour M, et al. Prevalence of intestinal parasites in food handlers of the city of Saqqez in 2016. J Parasit Dis 2019;43:113-9. DOI: https://doi.org/10.1007/s12639-018-1065-0

Beiromvand M, Mirrezaie E, Mirzavand S. Foodborne Giardiasis: Is there any relationship between food handlers and transmission of Giardia duodenalis? Infect Disord Drug Targets 2017;17:72-6. DOI: https://doi.org/10.2174/1871526517666170111105040

Azami M, Sharifi M, Hejazi SH, Tazhibi M. Intestinal parasitic infections in renal transplant recipients. Braz J Infect Dis 2010;14:15-8. DOI: https://doi.org/10.1590/S1413-86702010000100004

Agholi M, Hatam GR, Motazedian MH. HIV/AIDS-associated opportunistic protozoal diarrhea. AIDS Res Hum Retroviruses 2013;29:35-41. DOI: https://doi.org/10.1089/aid.2012.0119

Rasti S, Hassanzadeh M, Hooshyar H, et al. Intestinal parasitic infections in different groups of immunocompromised patients in Kashan and Qom cities, central Iran. Scand J Gastroenterol 2017;52:738-41. DOI: https://doi.org/10.1080/00365521.2017.1308547

Mahmoudi MR, Hasani H, Tsiami A, et al. Intestinal protozoan and helminthic infections among hemodialysis and cancer patients. Parasitol Res 2020;119:3053-9. DOI: https://doi.org/10.1007/s00436-020-06774-5

Esteghamati A, Khanaliha K, Bokharaei-Salim F, et al. Prevalence of intestinal parasitic infection in cancer, organ transplant and primary immunodeficiency patients in Tehran, Iran. Asian Pac J Cancer Prev 2019;20:495-501. DOI: https://doi.org/10.31557/APJCP.2019.20.2.495

Taghipour A, Azimi T, Javanmard E, et al. Immunocompromised patients with pulmonary tuberculosis; a susceptible group to intestinal parasites. Gastroenterol Hepatol Bed Bench 2018;11:S134-s9.

Shafiei Z, Esfandiari F, Sarkari B, et al. Parasitic infections in irritable bowel syndrome patients: evidence to propose a possible link, based on a case–control study in the south of Iran. BMC Res Notes 2020;13:1-5. DOI: https://doi.org/10.1186/s13104-020-05118-x

Jafari R, Gorgizadeh H, Soosaraei M, et al. Initial Evidences of Salt and Pepper Retinal Lesions (SPRL) in Patients with Intestinal Protozoan Infections in Iran. Infect Dis Drug Targets 2021;21:60-7. DOI: https://doi.org/10.2174/1871526520666200106124604

Tappeh Kh H, Mohammadzadeh H, Rahim RN, et al. Prevalence of intestinal parasitic infections among mentally disabled children and adults of Urmia, Iran. Iran J Parasitol 2010;5:60-4.

Sharif M, Daryani A, Asgarian F, Nasrolahei M. Intestinal parasitic infections among intellectual disability children in rehabilitation centers of northern Iran. Res Dev Disabil 2010;31:924-8. DOI: https://doi.org/10.1016/j.ridd.2010.03.001

Shokri A, Sarasiabi KS, Teshnizi SH, Mahmoodi H. Prevalence of Strongyloides stercoralis and other intestinal parasitic infections among mentally retarded residents in central institution of southern Iran. Asian Pac J Trop Biomed 2012;2:88-91. DOI: https://doi.org/10.1016/S2221-1691(11)60198-6

Saeidinia A, Tavakoli I, Naghipour MR, et al. Prevalence of Strongyloides stercoralis and other intestinal parasites among institutionalized mentally disabled individuals in Rasht, Northern Iran. Iran J Parasitol 2016;11:527-33.

Mohammadi-Meskin V, Hamedi Y, Heydari-Hengami M, et al. Intestinal parasitic infections in mental retardation center of Bandar Abbas, Southern Iran. Iran J Parasitol 2019;14:318-25. DOI: https://doi.org/10.18502/ijpa.v14i2.1145

Shahnazi M, Jafari-Sabet M. Prevalence of parasitic contamination of raw vegetables in villages of Qazvin Province, Iran. Foodborne Pathog Dis 2010;7:1025-30. DOI: https://doi.org/10.1089/fpd.2009.0477

Isazadeh M, Mirzaii-Dizgah I, Shaddel M, Homayouni MM. The prevalence of parasitic contamination of fresh vegetables in Tehran, Iran. Turkiye Parazitol Derg 2020;44:143-8. DOI: https://doi.org/10.4274/tpd.galenos.2020.6469

Kia EB, Hosseini M, Nilforoushan MR, et al. Study of intestinal protozoan parasites in rural inhabitants of Mazandaran Province, Northern Iran. Iran J Parasitol 1970;3.

Sadjjadi S, Massoud J. Prevalence pattern of Giardia lamblia in the rural areas in the north of Iran. Giardia from Molecules to Diseases 1994:365.

Sharifi I, Keshavarz H. The prevalence of intestinal in 1 to 11 year old children in Kerman. J Drug Treat 1993;121:7-11.

Sharafi M. Prevalence of intestinal parasites in student of elementary school, Bandar Abbas. J Hormoz Univ Med Sci 2011;29:4.

Mohandas, Sehgal R, Sud A, Malla N. Prevalence of Intestinal Parasitic pathogens in HIV-Seropositive Individuals in Northen India. Jpn J Infect Dis 2002;55:83-4.

Gautam H, Bhalla P, Saini S, et al. Epidemiology of opportunistic infections and its correlation with CD4 T-lymphocyte counts and plasma viral load among HIV-positive patients at a tertiary care hospital in India. J Int Ass Physicians AIDS Care 2009;8:333-7. DOI: https://doi.org/10.1177/1545109709346881

Zali MR, Mehr AJ, Rezaian M, et al. Prevalence of intestinal parasitic pathogens among HIV-positive individuals in Iran. Jpn J Infect Dis 2004;57:268-70.

Taherkhani H. Prevalence of intestinal parasites in mentally disabled students in Hamedan 2000. Jundishapur Sci Med J 2002;32:58-63.

Mowlavi G, MirAhmadi H, Rezaeian M, et al. Prevalence of intestinal parasites in tribal parts of Khuzestan Province during 2005-07. Govaresh 2012;12:10.

Zare Bavani M, Rezaian M, Jedi Tehrani M, Kazemi B. Application of PCR-RFLP for identification of Giardia isolates of human in Iran. Cell Journal (Yakhteh) 2002;4.

Babaei Z, Oormazdi H, Akhlaghi L, et al. Molecular characterization of the Iranian isolates of Giardia lamblia: application of the glutamate dehydrogenase gene. Iranian J Publ Health 2008;37:75-82.

Fallah E, Nahavandi KH, Jamali R, et al. Molecular identification of Giardia duodenalis isolates from human and animal reservoirs by PCR-RFLP. J Biol Sci 2008;8:896-901. DOI: https://doi.org/10.3923/jbs.2008.896.901

Etemadi S, Ziyaali N, Babaei Z, et al. The correlation between clinical signs and genotypes of Giardia duodenalis isolated from patients with Giardiasis in Kerman City. J Kerman Univ Med Sci 2011;18:330-9.

Nahavandi KH, Fallah E, Asgharzadeh M, et al. Glutamate dehydrogenase and triose-phosphate-isomerase coding genes for detection and genetic characterization of Giardia lamblia in human feces by PCR and PCR-RFLP. Turkish J Med Sci 2011;41:283-9.

Akbarian A, Sadraie J, Forozandeh M. Evaluattion of Giardia lamblia genetic differences in Khorramabad City and surrounding villages by use of PCR and sequencing. Sci J Kurdistan Univ Med Sci 2012;17:61-71.

Sarkari B, Ashrafmansori A, Hatam GR, et al. Genotyping of Giardia lamblia isolates from human in southern Iran. Trop Biomed 2012;29:366-71.

Manouchehri Naeini K, Hosseini SA, Gholipour A, et al. Genotyping of Giardia duodenalis isolates in individuals with and without chronic diarrhea using Polymerase Chain Reaction. J Mazandaran Univ Med Sci 2012;22:39-46.

Rayani M, Hatam G, Unyah NZ, et al. Phylogenetic analysis of Giardia lamblia human genotypes in Fars Province, southern Iran. Iran J Parasitol 2017;12:522-33.

Kialashaki E, Fakhar M, Sharif M, et al. The mixed AII and BIII genotypes of human Giardia lamblia isolate circulating in Mazandaran Province, Northern Iran. Infect Disord Drug Targets 2020;20:834-9. DOI: https://doi.org/10.2174/1871526520666200127155118

Roointan ES, Rafiei A, Samarbaf-Zadeh AR, et al. Molecular identification of Giardia lamblia isolates from adult human cases in southwest of Iran. Afr J Biotechnol 2013;12:901-6.

Pestehchian N, Rasekh H, Babaei Z, et al. Identification of genotypes of Giardia duodenalis human isolates in Isfahan, Iran, using polymerase chain reaction – Restriction Fragment Length polymorphism. Adv Biomed Res 2012;1:84. DOI: https://doi.org/10.4103/2277-9175.105166

Hazrati Tappeh K, Manafi G, Asgharzadeh M, Manafi F. Incidence of Giardia lamblia Subspecies by PCR-RFLP in Stool Specimens of Hospitalized Children at Urmia Mutahhari Hospital, West Azerbaijan Province, Iran. Iran J Parasitol 2014;9:541-7.

Mirzavand S, Kohansal K, Beiromvand M. Molecular genotyping of Giardia duodenalis in municipal waste workers in Ahvaz, southwestern Iran. Trop Biomed 2019;36:44-52.

Kashinahanji M, Haghighi A, Bahrami F, et al. Giardia lamblia assemblages A and B isolated from symptomatic and asymptomatic persons in Hamadan, west of Iran. J Parasit Dis 2019;43:616-23. DOI: https://doi.org/10.1007/s12639-019-01139-x

Rahimian F, Sadraei J, Pirestani M, Ghaffarifar F. A modified PCR-RFLP method to determine genetic diversity of Giardia lamblia human isolates based on triosephosphate isomerase (TPI) gene. Acta Trop 2018;186:58-62. DOI: https://doi.org/10.1016/j.actatropica.2018.06.008

Hooshyar H, Ghafarinasab S, Arbabi M, et al. Genetic variation of Giardia lamblia isolates from food-handlers in Kashan, Central Iran. Iran J Parasitol 2017;12:83-9.

Shahdoust S, Niyyati M, Haghighi A, et al. Prevalence of intestinal parasites in referred individuals to the medical centers of Tonekabon city, Mazandaran province. Gastroenterol Hepatol Bed Bench 2016;9:S75-S9.

Shahnazi M, Naghizadeh F, Hajialilo E, et al. Investigation of Giardia intestinalis Genotypes among the Food Handlers of Qazvin, Iran. Iran J Parasitol 2019;14:534-41. DOI: https://doi.org/10.18502/ijpa.v14i4.2095

Nasiri Goorabi L, Pirestani M, Sadraei J. Genotyping of Giardia Duodenalis by β-giardin gene in asymptomatic patients. J Mazandaran Univ Med Sci 2017;27:27-34.

Effati F, Dalimi AH, Pirestani M. A survey on Giardia and Cryptosporidium infection and genotyping common Giardia in children in Alborz Province. Pathobiol Res 2018;21:133-9.

Siyadatpanah A, Sharif M, Daryani A, et al. Spatial distribution of Giardia lamblia infection among general population in Mazandaran Province, north of Iran. J Parasit Dis 2018;42:171-6. DOI: https://doi.org/10.1007/s12639-018-0976-0

Sepahvand A, Hosseini-Safa A, Yousofi HA, Tajedini MH, Gharehbabah RP, Pestehchian N. Genotype Characteristics of Giardia duodenalis in Patients Using High Resolution Melting Analysis Technique in Khorramabad, Iran. Iran J Parasitol 2020;15:204. DOI: https://doi.org/10.18502/ijpa.v15i2.3302

Kasaei R, Carmena D, Jelowdar A, Beiromvand M. Molecular genotyping of Giardia duodenalis in children from Behbahan, southwestern Iran. Parasitol Res 2018;117:1425-31. DOI: https://doi.org/10.1007/s00436-018-5826-6

Mahmoudi MR, Mahdavi F, Ashrafi K, et al. Report of Giardia assemblages and giardiasis in residents of Guilan province-Iran. Parasitol Res 2020;119:1083-91. DOI: https://doi.org/10.1007/s00436-019-06595-1

Bahrami F, Zamini GH, Haghighi A, Khademerfan MB. Detection and molecular identification of human giardia isolates in the west of Iran. Biomed Res (India) 2017;28:5687-92.

Ayatollahi J, Mousavi SA, Hafizi M, et al. The Prevalence of Intestinal Parasites in the Samples Collected from the Central Laboratory of Borujen, Iran. Jentashapir J Cell Mol Biol 2018;9:e83692. DOI: https://doi.org/10.5812/jjhr.83692

Rafiei A, Roointan ES, Samarbafzadeh AR, et al. Investigation of possible correlation between Giardia duodenalis genotypes and clinical symptoms in southwest of Iran. Iran J Parasitol 2013;8:389-95.

Mirrezaie E, Beiromvand M, Tavalla M, Teimoori A, Mirzavand S. Molecular Genotyping of Giardia duodenalis in Humans in the Andimeshk County, Southwestern Iran. Acta Parasitologica 2019;64:376-83. DOI: https://doi.org/10.2478/s11686-019-00051-x

Khamesipour, F., Chelgerdi Dehkordi, B., Afzal, S.-S., Kheyri, P., Nezaratizadeh, S., Shojaat, S., & Hejazi, S. H. (2021). A review of giardiasis and its parasite genotypes in Iran. Infectious Diseases and Herbal Medicine, 2(1). https://doi.org/10.4081/idhm.2021.126

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