Conventional medicines used for kidney protection in Bangladesh: a review


Submitted: 17 April 2023
Accepted: 28 July 2023
Published: 12 September 2023
Abstract Views: 168
SUPPLEMENTARY PDF: 35
PDF: 21
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

To describe the kidney's response to specific substances, such as dangerous compounds and pharmaceuticals, the term "nephrotoxicity" is employed. When the body is subjected to toxins or medications, nephrotoxicity is among the most prevalent side effects. Numerous medical treatments, including anti-cancer medicines, antibiotics, and some Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), can cause nephrotoxicity. This review discusses a variety of drugs that can preserve the kidneys. The nephroprotective qualities of natural substances, medicinal plants, and dietary components have been examined. Medicinal plant chemicals have a significant role in pharmaceutical research. A wide range of herbs has been shown to have nephroprotective effects. Treatment of renal calculi, prevention of diabetic nephropathy, and reduction in tubular damage were all achieved. Plant-based therapies contain phytochemicals that have nephroprotective properties. Plants with nephroprotective activities have been reported on cisplatin, gentamicin, adriamycin, and urolithiasis, caffeic acid phenethyl ester assists in nephrotoxicity and free radicals radical scavenging activity, which may be utilized to prevent and treat kidney damage. In the end, investigating traditional medicines from Bangladesh that contain kidney-protecting plants is an intriguing new avenue of inquiry that could lead to effective new therapies for renal illnesses. Maintaining kidney health and enhancing the lives of countless people is only possible with further investigation into the beneficial effects of plants on renal function. However, it is crucial to find a middle ground between ancient practices and evidence-based modern medicine, stressing the importance of making educated decisions and following expert guidance to guarantee uncompromised kidney health.


Anger EE, Yu F, Li J. Aristolochic acid-induced nephrotoxicity: molecular mechanisms and potential protective approaches. International Journal of Molecular Sciences. 2020;21:1157.

Das S, Vasudeva N, Sharma S. Kidney disorders and management through herbs: A Review. J. Phytopharm. 2019;8:21-7.

Efferth T, Saeed ME, Mirghani E, et al. Integration of phytochemicals and phytotherapy into cancer precision medicine. Oncotarget. 2017;8:50284.

Governa P, Baini G, Borgonetti V, et al. Phytotherapy in the management of diabetes: a review. Molecules. 2018;23:105.

Sabiu S, O’Neill FH, Ashafa AO. The purview of phytotherapy in the management of kidney disorders: a systematic review on Nigeria and South Africa. African Journal of Traditional, Complementary and Alternative Medicines. 2016;13:38-47.

Basist P, Parveen B, Zahiruddin S, et al. Potential nephroprotective phytochemicals: Mechanism and future prospects. Journal of ethnopharmacology. 2022;283:114743.

Dwyer JT, Coates PM, Smith MJ. Dietary supplements: regulatory challenges and research resources. Nutrients. 2018;10:41.

Whelton A. Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications. The American journal of medicine. 1999;106:13S-24S.

Rizvi M, Khan F, Shukla I, Khan AA. Comparative nephrotoxicity of gentamicin, tobramycin, and amikacin. Journal of clinical pharmacy and therapeutics. 2011;36:110-7.

McCullough PA. Contrast-induced acute kidney injury. Journal of the American College of Cardiology. 2008;51:1419-28.

Perazella MA. Pharmacology behind common drug nephrotoxicities. Clinical journal of the American Society of Nephrology: CJASN. 2018;13:1897.

Shimmi SC, Jahan N, Sultana N. Effect of Ashwagandha (Withania somnifera) root extract against gentamicin induced changes of serum urea and creatinine levels in rats. Journal of Bangladesh Society of Physiologist. 2011;6:84-9.

Pfaller W, Gstraunthaler G. Nephrotoxicity testing in vitro--what we know and what we need to know. Environmental health perspectives. 1998;106:559-69.

Gingell JC, Waterworth PM. Dose of gentamicin in patients with normal renal function and renal impairment. British Medical Journal. 1968;2:19.

Gibson TP. Renal disease and drug metabolism: an overview. American Journal of Kidney Diseases. 1986;8:7-17.

Miller RP, Tadagavadi RK, Ramesh G, Reeves WB. Mechanisms of cisplatin nephrotoxicity. Toxins. 2010;2:2490-518.

Zimmerman JL, editor. Toxicology, An Issue of Critical Care Clinics. Elsevier, Amsterdam, The Netherlands. 2021. 240 pp.

Massa FM. The crucial roles played by HNF1β during kidney development (Doctoral dissertation; Université René Descartes, Paris V, France, 2012). Available from: https://theses.hal.science/tel-00771435/file/va_Massa_Filippo.pdf

Michael A, Faga T, Pisani A, et al. Molecular mechanisms of renal cellular nephrotoxicity due to radiocontrast media. BioMed research international. 2014;2014:249810.

Duggal N. Evaluation of Nephroprotective Activity of Gallic Acid in Gentamicin-induced rat Model of Nephrotoxicity. International Journal of Green Pharmacy (IJGP). 2018;12.

Makris K, Spanou L. Acute kidney injury: definition, pathophysiology and clinical phenotypes. The clinical biochemist reviews. 2016;37:85.

Harikrishnan B, Subramanian P, Subash S. Effect of Withania somnifera root powder on the levels of circulatory lipid peroxidation and liver marker enzymes in chronic hyperammonemia. Journal of Chemistry. 2008;5:872-7.

Movaliya V, Khamar D, Setty M. Nephroprotective activity of aqueous extract of Aerva Javanica roots in cisplatin induced renal toxicity in rats. Pharmacologyonline. 2011;1:68-74.

Debnath S, Babre N, Manjunath YS, et al. Nephroprotective evaluation of ethanolic extract of the seeds of papaya and pumpkin fruit in cisplatin-induced nephrotoxicity. J Pharm Sci Technol. 2010;2:241-6.

Gaikwad K, Dagle P, Choughule P, et al. A review on some nephroprotective medicinal plants. International journal of pharmaceutical sciences and research. 2012;3:2451.

Adikay S, Koganti B, Prasad KV. Effect of alcoholic extract of roots of Dichrostachys cinerea Wight & Arn. against cisplatin-induced nephrotoxicity in rats. Natural Product Radiance. 2009;8:12-18.

Azu OO, Francis I, Abraham A, et al. Protective agent, Kigelia Africana fruit extract, against cisplatin-induced kidney oxidant injury in Sprague–Dawley rats. Asian J Pharma Clin Res. 2010;3:84-8.

Yadav YC, Srivastav DN, Seth AK, et al. Nephropharmacological activity of ethanolic extract Lepidium sativum L. Seeds in albino rats using cisplatin induced acute renal failure. Int J Pharm Sci Rev Res. 2010;4:64-8.

Shelke TT, Kothai R, Adkar PP, et al. Nephroprotective activity of ethanolic extract of dried fruits of Pedalium murex Linn. Journal of Cell and tissue research. 2009;9:1687.

Sreedevi A, Bharathi K, Prasad KV. Effect of Vernonia cinerea aerial parts against Cisplatin-induced nephrotoxicity in rats. Pharmacologyonline. 2011;2:548-55.

Kore KJ, Shete RV, Jadhav PJ. RP-HPLC method of simultaneous nephroprotective role of A. marmelos extract. Int J Res Pharm Chem. 2011;1:617-23.

Bibu KJ, Joy AD, Mercey KA. Therapeutic effect of ethanolic extract of Hygrophila spinosa T. Anders on gentamicin-induced nephrotoxicity in rats. 2010;48:911-7.

Harlalka GV, Patil CR, Patil MR. Protective effect of Kalanchoe pinnata pers.(Crassulaceae) on gentamicin-induced nephrotoxicity in rats. Indian journal of pharmacology. 2007;39:201.

Shenoy JP, Pai PG, Shoeb A, et al. An evaluation of diuretic activity of Morinda citrifolia (Linn)(noni) fruit juice in normal rats. International Journal of Pharmacy and Pharmaceutical Sciences. 2011;3(2):119-21.

Mannavalan R. Evaluation of nephroprotective activity of Orthosiphon stamineus Benth extract using rat model. EVALUATION. 2010;2:209-15.

Porter GA, Bennett WM. Nephrotoxic acute renal failure due to common drugs. American Journal of Physiology-Renal Physiology. 1981;241:F1-8.

Ichikawa H, Takada Y, Shishodia S, et al. Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB–regulated gene expression. Molecular cancer therapeutics. 2006;5:1434-45.

Pathan N. A Systematic Review on Nephroprotective Plants. International Journal of Research Publication and Reviews. 2021;2:174-84.

Linkermann A, Chen G, Dong G, et al. Regulated cell death in AKI. Journal of the American Society of Nephrology: JASN. 2014;25:2689.

Latif A, Hussain K, Shehzadi N, et al. Glutathione sulfotransferase inhibition activity of a self-fermented beverage, Kanji. Pharmaceutical biology. 2017;55:547-53.

Somani SM, Husain K, Whitworth C, et al. Dose‐dependent protection by lipoic acid against cisplatin‐induced nephrotoxicity in rats: antioxidant defense system. Pharmacology & toxicology. 2000;86:234-41.

Anwar R, Sultan R, Batool F. Ameliorating effect of Berberis lycium root bark extracts against cisplatin-induced nephropathy in rat. ||| Bangladesh Journal of Pharmacology|||. 2018;13:248-54.

Hashmi N, Muhammad F, Javed I, et al. Nephroprotective effects of Ficus religiosa linn (peepal plant) stem bark against isoniazid and rifampicin induced nephrotoxicity in albino rabbits. Pak Vet J. 2013;33:330-4.

Johansson LH, Borg LH. A spectrophotometric method for determination of catalase activity in small tissue samples. Analytical biochemistry. 1988;174:331-6.

Sinha AK. Colorimetric assay of catalase. Analytical biochemistry. 1972;47:389-94.

Khan MR, Rizvi W, Khan GN, Khan RA, Shaheen S. Carbon tetrachloride-induced nephrotoxicity in rats: Protective role of Digera muricata. Journal of ethnopharmacology. 2009;122:91-9.

Rahman AS, Habib A, Parvin N, Chowdhury MR. Nephroprotective Effects of Dioscoreaalata and Moriengaolifera on Cisplatin Induced Nephrotoxicity in Rats. TAJ: Journal of Teachers Association. 2018;31:46-51.

Iqbal S, Bhanger MI. Effect of season and production location on antioxidant activity of Moringa oleifera leaves grown in Pakistan. Journal of food Composition and Analysis. 2006;19:544-51.

Rahman F, Begum M, Chowdhury R. Nephroprotective effect of Aloe barbadensis Miller against gentamicin induced nephrotoxicity in long evans male rats. Journal of Bangladesh Society of Physiologist. 2021;16:33-8.

Hasan MM, Tasmin MS, El-Shehawi AM, et al. R. vesicarius L. exerts nephroprotective effect against cisplatin-induced oxidative stress. BMC Complementary Medicine and Therapies. 2021;21:1-2.

Marinas IC, Oprea E, Chifiriuc MC, et al. Chemical composition and antipathogenic activity of Artemisia annua essential oil from Romania. Chemistry & Biodiversity. 2015;12:1554-64.

Gonçalves DD, Soares AA, Jacomassi E, et al. Antimicrobial activity of species Zingiber officinale Roscoe and Alpinia purpurata (Vieill.) K. Schum.(Zingiberaceae)-Review. Semina: Ciências Agrárias. 2018;39:1849-61.

Afzal A, Oriqat G, Akram Khan M, et al. Chemistry and biochemistry of terpenoids from Curcuma and related species. Journal of Biologically Active Products from Nature. 2013;3:1-55.

Imanshahidi M, Hosseinzadeh H. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytotherapy research. 2008;22:999-1012.

Vargas F, Romecín P, García-Guillén AI, et al. Flavonoids in kidney health and disease. Frontiers in physiology. 2018;9:394.

Mirmiran P, Yuzbashian E, Rahbarinejad P, et al. Dietary intakes of total polyphenol and its subclasses in association with the incidence of chronic kidney diseases: a prospective population‐based cohort study. BMC nephrology. 2021;22:1-7.

Naderi E, Rad AK, Nazari S, et al. Nigella sativa and its main constituent, thymoquinone protect against glycerol-induced acute kidney injury in rats. Avicenna Journal of Phytomedicine. 2022;12:638.

Shin BK, Kwon SW, Park JH. Chemical diversity of ginseng saponins from Panax ginseng. Journal of ginseng research. 2015;39:287-98.

Qian Y, Sun X, Wang X, et al. Mechanism of Cordyceps Cicadae in treating diabetic nephropathy based on network pharmacology and molecular docking analysis. Journal of Diabetes Research. 2021;2021:5477941.

Sundararajan R, Bharampuram A, Koduru R. A review on phytoconstituents for nephroprotective activity. Pharmacophore. 2014;5:160-82.

Zishan, S. A., Uddin, M. I., Naima, J., & Ibban, S. (2023). Conventional medicines used for kidney protection in Bangladesh: a review. Infectious Diseases and Herbal Medicine, 4(1). https://doi.org/10.4081/idhm.2023.328

Downloads

Download data is not yet available.

Citations