How systems biology of cancer signaling pathways can inform optimized combination chemotherapy design
https://doi.org/10.4081/bse.143
Published: 29 September 2021
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
This talk presents an overview of the systems biology of cancer applied to specific protein-protein interaction signaling pathways. We argue that network analysis augmented with thermodynamics measures such as Gibbs free energy can lead to optimized design of drug combinations for cancer chemotherapy.
Tuszynski, J. A., & Rietman, E. A. (2021). How systems biology of cancer signaling pathways can inform optimized combination chemotherapy design. Biomedical Science and Engineering, 3(1). https://doi.org/10.4081/bse.143
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