Development of a multiscale testing method for the reduction of soft biological tissues waste during mechanical characterization
https://doi.org/10.4081/bse.176
Published: 29 September 2021
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Two biaxial mechanical test methods were devised to compare their suitability for the mechanical characterization of soft biological tissues with the least possible tissue waste. Nanoindentation was used to explore the microscopic properties of the tissue and to overcome the macroscopic test limitations.
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2. Hiester ED, Sacks MS. Optimal bovine pericardial tissue selection sites. I. Fiber architecture and tissue thickness measurements. J Biomed Mater Res 1998;39:207–14.
3. Hiester ED, Sacks MS. Optimal bovine pericardial tissue selection sites. II. Cartographic analysis. J Biomed Mater Res 1998;39:215–221.
4. Billiar KL, Sacks MS. Biaxial mechanical properties of the natural and glutaraldehyde treated aortic valve cusp--Part I: Experimental results. J Biomech Eng 2000;122:23-30.
5. Sun W, Sacks MS, Sellaro TL, et al. Biaxial mechanical response of bioprosthetic heart valve biomaterials to high in-plane shear. ASME. J Biomech Eng 2003;125:372–80.
6. Sacks MS, Sun W. Multiaxial mechanical behavior of biological materials. Annu Rev Biomed Eng 2003;5:251-84.
Lugas, A. T., Serino, G., Terzini, M., Bignardi, C., & Audenino, A. L. (2021). Development of a multiscale testing method for the reduction of soft biological tissues waste during mechanical characterization. Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.176
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