3F(eature)s model: modularity, heterogeneity and three-dimensionality to design in vitro neuronal model


Published: 29 September 2021
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Authors

  • Martina Brofiga Department of Informatics, Bioengineering, Robotics and Systems Engineering (DIBRIS) University of Genova, Genova, Italy.
  • Marietta Pisano Department of Informatics, Bioengineering, Robotics and Systems Engineering (DIBRIS) University of Genova, Genova, Italy.
  • Mariateresa Tedesco Brain AG, Switzerland.
  • Francesca Callegari Department of Informatics, Bioengineering, Robotics and Systems Engineering (DIBRIS) University of Genova, Genova, Italy.
  • Paolo Massobrio Department of Informatics, Bioengineering, Robotics and Systems Engineering (DIBRIS) University of Genova, Genova; National Institute for Nuclear Physics (INFN), Genova, Italy.

In this work, we present a novel experimental platform to build in vitro interconnected (i.e., modular) heterogeneous (e.g., cortical-hippocampal) and three-dimensional (3D) neuronal cultures plated on Micro-Electrode Arrays (MEAs) to extracellularly record the electrophysiological activity continuously.


Brofiga, M., Pisano, M., Tedesco, M., Callegari, F., & Massobrio, P. (2021). 3F(eature)s model: modularity, heterogeneity and three-dimensionality to design <em>in vitro</em> neuronal model. Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.158

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