Drug-induced hepatotoxicity studied in a 3D, in vitro model of the liver


https://doi.org/10.4081/bse.172
Vol. 2 No. 1 (2021)
Published: 29 September 2021
Hepatotoxicity, in vitro models, 3D models, alternative models
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Authors

  • Giuseppe Guagliano
    giuseppe.guagliano@polimi.it
    Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milan, Italy.
  • Manuela Legnardim Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milan, Italy.
  • Cristina Volpini Molecular Medicine Department (DMM), Center for Health Technologies (CHT), UdR INSTM, University of Pavia, Pavia, Italy.
  • Nora Bloise Molecular Medicine Department (DMM), Center for Health Technologies (CHT), UdR INSTM, University of Pavia, Pavia, Italy.
  • Silvia Dotti National Reference Center for Alternative Methods, Welfare and Care of Laboratory Animals, Istituto Zooprofilattico Sperimentale della Lomabardia ed Emilia Romagna, Brescia, Italy.
  • Riccardo Villa National Reference Center for Alternative Methods, Welfare and Care of Laboratory Animals, Istituto Zooprofilattico Sperimentale della Lomabardia ed Emilia Romagna, Brescia, Italy.
  • Livia Visai Molecular Medicine Department (DMM), Center for Health Technologies (CHT), UdR INSTM, University of Pavia, Pavia; Medicina Clinica-Specialistica, UOR5 Laboratorio di Nanotecnologie, ICS Maugeri, IRCCS Pavia, Italy.
  • Paola Petrini Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milan, Italy.

Drug development is a high failure rate process; too many drugs fail during clinical trials because of severe hepatotoxicity. This situation can be significantly improved by redesigning preclinical trials, and privileging the use of high-throughput in vitro models, by combining cell-based in vitro models and material-based models.


Guagliano, G., Legnardim, M., Volpini, C., Bloise, N., Dotti, S., Villa, R., Visai, L., & Petrini, P. (2021). Drug-induced hepatotoxicity studied in a 3D, <em>in vitro</em> model of the liver. Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.172

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