Platelet rich plasma enhancement of skin regeneration in an ex vivo human experimental model


https://doi.org/10.4081/bse.98
Vol. 1 No. 1 (2020)
Published: 12 February 2020
Platelet rich plasma, Regeneration, ex vivo, collagen, elastic fibers
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Authors

  • Giovanni Nicoletti
    giovanni.nicoletti@unipv.it
    Plastic and Reconstructive Surgery, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia; Plastic and Reconstructive Surgery Unit, Department of Surgery, Istituti Clinici Scientifici Maugeri, Pavia, Italy.
  • Marco Saler Plastic and Reconstructive Surgery, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
  • Laura Villani
  • Agnese Rumolo Plastic and Reconstructive Surgery, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
  • Marco Mario Tresoldi Plastic and Reconstructive Surgery, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia; Plastic and Reconstructive Surgery Unit, Department of Surgery, Istituti Clinici Scientifici Maugeri, Pavia, Italy.
  • Angela Faga Advanced Technologies for Regenerative Medicine and Inductive Surgery Research Center, University of Pavia, Pavia, Italy.

An original ex vivo wounded skin culture protocol using autologous Platelet Rich Plasma (PRP) and enriched Dulbecco’s Modified Eagle’s Medium demonstrated a favourable modulation of the epithelial cells and fibroblasts proliferation, a relevant antiinflammatory action and a favourable modulation of the re-organization of collagen and elastic fibres. The step by step regenerative effects of PRP on human skin wound repair and regeneration process was observed over a period of 10 days.


Nicoletti, G., Saler, M., Villani, L., Rumolo, A., Tresoldi, M. M., & Faga, A. (2020). Platelet rich plasma enhancement of skin regeneration in an ex vivo human experimental model. Biomedical Science and Engineering, 1(1). https://doi.org/10.4081/bse.98

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