The anxiety and depression disorder in adults with atopic dermatitis: experience of a dermatology hospital


Published: 6 July 2022
Abstract Views: 1491
PDF: 413
HTML: 11
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

The objectives of this study are to identify the proportion of atopic dermatitis adult patients having anxiety and depression disorder and to measure the relationship between anxiety and depression disorder and characteristics of atopic dermatitis. A cross-sectional study with convenience sampling was conducted. Diagnostic criteria for atopic dermatitis were based on modified Hanifin and Raijka criteria and the severity of anxiety-depression disorder was evaluated using the hospital anxiety and depression scale. In this study, 208 patients were enrolled. The percentage of patients with anxiety and subthreshold anxiety were 11.1% and 34.1%, respectively. 5.3% of patients had depression and 39.4% of patients suffered from subthreshold depression. The proportion of patients with mixed anxiety-depressive disorder was 1.44%. Patients with severe atopic dermatitis were more likely to endure anxiety but not depression. Allergies or autoimmune diseases and scoring atopic dermatitis C were two independent risk factors of depression whereas edema and excoriation were two independent risk factors related to anxiety in atopic dermatitis patients. These findings suggest that atopic dermatitis is associated with anxiety and depression. Allergies, autoimmune diseases, pruritus, and insomnia had a correlation with anxiety and depression disorder.


Beattie PE, Lewis-Jones MS. A comparative study of impairment of quality of life in children with skin disease and children with other chronic childhood diseases. Br J Dermatol 2006;155:145-51.

Kaaz K, Szepietowski JC, Matusiak Ł. Influence of itch and pain on sleep quality in atopic dermatitis and psoriasis. Acta Derm Venereol 2019;99:175-80.

Zy Lim V, Cm Ho R, Tee SI, et al. Anxiety and depression in patients with atopic dermatitis in a Southeast Asian tertiary dermatological centre. Ann Acad Med Singap 2016;45:451-5.

Silverberg JI, Gelfand JM, Margolis DJ, et al. Symptoms and diagnosis of anxiety and depression in atopic dermatitis in US adults. Br J Dermatol 2019; 181:554-65.

Sherry HY, Silverberg J. Association between atopic dermatitis and depression in US adults. J Invest Dermatol 2015;135:3183-6.

Gupta MA, Gupta AK. Depression and suicidal ideation in dermatology patients with acne, alopecia areata, atopic dermatitis and psoriasis. Br J Dermatol 1998;139:846-50.

Ring J, Zink A, Arents BWM, et al. Atopic eczema: burden of disease and individual suffering–results from a large EU study in adults. J Eur Acad Dermatol Venereol 2019;33:1331-40.

Bender BG, Ballard R, Canono B, et al. Disease severity, scratching, and sleep quality in patients with atopic dermatitis. J Am Acad Dermatol 2008;58:415-20.

Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67:361-70.

Tiểu Vi NTTT, Thế Trung V. Serum total and specific IgE level in atopic dermatitis patients at Ho Chi Minh city Hospital of Dermatology and Venereology. Ho Chi Minh City J Med 2018;22:58-65.

Silverberg J. Public health burden and epidemiology of atopic dermatitis. Dermatol Clin 2017;35:283-9.

Danesh MJ, Murase JE. A review of the clinical and immunologic effects of estrogen on atopic dermatitis. Int J Gynaecol Obstet 2015; 2:100-3.

Stefanovic N, Irvine AD, Flohr C. The role of the environment and exposome in atopic dermatitis. Curr Treat Options Allergy 2021;8:222-41.

Bruin-Weller M, Gadkari A, Auziere S, et al. The patient-reported disease burden in adults with atopic dermatitis: a cross-sectional study in Europe and Canada. J Eur Acad Dermatol Venereol 2020;34:1026-36.

Hanifin JM. Adult-onset atopic dermatitis: fact or fancy?. Dermatol Clin 2017; 35:299-302.

Tsintsadze N, Beridze L, Krichun Y, et al. Psychosomatic aspects in patients with dermatologic diseases. Georgian Med News 2015:70-5.

Kapoor R, Menon C, Hoffstad O, et al. The prevalence of atopic triad in children with physician-confirmed atopic dermatitis. J Am Acad DermatoL 2008;58:68-73.

Pourpak Z, Farhoudi A, Mahmoudi M, et al. The role of cow milk allergy in increasing the severity of atopic dermatitis. Immunol Invest 2004;33:69-79.

Eichenfield L F, Tom WL, Chamlin SL et al. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol 2014;70:338-51.

Eichenfield LF, Tom WL, Berger TG, et al. Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies. J Am Acad Dermatol 2014;71:116-32.

Whiteley J, Emir B, Seitzman R, Makinson G. The burden of atopic dermatitis in US adults: results from the 2013 National Health and Wellness Survey. Curr Med Res Opin 2016;32;1645-51.

Møller Rønnstad AT, Halling-Overgaard AS, Hamann CR, et al. Association of atopic dermatitis with depression, anxiety, and suicidal ideation in children and adults: a systematic review and meta-analysis. J Am Acad Dermatol 2018;79:448-56.

Simpson EL, Guttman-Yassky E, Margolis DJ, et al. Association of inadequately controlled disease and disease severity with patient-reported disease burden in adults with atopic dermatitis. JAMA Dermatol 2018;154:903-12.

Simpson EL, Bieber T, Eckert L, et al. Patient burden of moderate to severe atopic dermatitis (AD): insights from a phase 2b clinical trial of dupilumab in adults. J Am Acad Dermatol 2016;74:491-8.

Kim SH, Hur J, Jang JY, et al. Psychological distress in young adult males with atopic dermatitis: a cross-sectional study. Medicine 2015;94:e949.

Tsuno N, Besset A, Ritchie K. Sleep and depression. J Clin Psychiatry 2005;66:1254-69.

Halvorsen JA, Stern RS, Dalgard F, et al. Suicidal ideation, mental health problems, and social impairment are increased in adolescents with acne: a population-based study. J Invest Dermatol 2011;131:363-70.

Schut C, Bosbach S, Gieler U, Kupfer J. Personality traits, depression and itch in patients with atopic dermatitis in an experimental setting: a regression analysis. Acta Derm Venereol 2014;94:20-5.

Vinh , N. M., Trang, V. T. T., Dac Thuy, L. N., Tam , H. T. X., Hang , L. T. T., & Bac , P. V. (2022). The anxiety and depression disorder in adults with atopic dermatitis: experience of a dermatology hospital. Dermatology Reports, 15(1). https://doi.org/10.4081/dr.2022.9524

Downloads

Download data is not yet available.

Citations